Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics

The effects of phosphorylation of a serine residue on the structural and dynamic properties of Ras-like protein, Rap, and its interactions with effector protein Ras binding domain (RBD) of Raf kinase, in the presence of GTP, are investigated via molecular dynamics simulations. The simulations show t...

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Detalles Bibliográficos
Autores principales: T, Devanand, Venkatraman, Prasanna, Vemparala, Satyavani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113251/
https://www.ncbi.nlm.nih.gov/pubmed/30154518
http://dx.doi.org/10.1038/s41598-018-31234-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113251/
https://www.ncbi.nlm.nih.gov/pubmed/30154518
http://dx.doi.org/10.1038/s41598-018-31234-7

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