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Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics
The effects of phosphorylation of a serine residue on the structural and dynamic properties of Ras-like protein, Rap, and its interactions with effector protein Ras binding domain (RBD) of Raf kinase, in the presence of GTP, are investigated via molecular dynamics simulations. The simulations show t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113251/ https://www.ncbi.nlm.nih.gov/pubmed/30154518 http://dx.doi.org/10.1038/s41598-018-31234-7 |