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Mammalian prion propagation in PrP transgenic Drosophila

Mammalian prions propagate by template-directed misfolding and aggregation of normal cellular prion related protein PrP(C) as it converts into disease-associated conformers collectively referred to as PrP(Sc). Mammalian species may be permissive for prion disease because these hosts have co-evolved...

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Detalles Bibliográficos
Autores principales: Thackray, Alana M, Andréoletti, Olivier, Bujdoso, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113635/
https://www.ncbi.nlm.nih.gov/pubmed/29985975
http://dx.doi.org/10.1093/brain/awy183