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Quick and sustained clinical response to MEK inhibitor I in a NF1 patient with neurofibromas
Neurofibromatosis 1 (NF1) is an autosomal dominant tumour predisposition disorder with a birth incidence of about 1 in 2,700 and prevalence of 1 in 4,560. The NF1 gene codes for an ubiquitous protein: neurofibromin. Neurofibromin interacts with the proto-oncogene RAS to suppress tumour formation. In...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cancer Intelligence
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113984/ https://www.ncbi.nlm.nih.gov/pubmed/30174724 http://dx.doi.org/10.3332/ecancer.2018.862 |