Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity

A series of aminophenylhydroxamates and aminobenzylhydroxamates were synthesized and screened for their antiparasitic activity against Leishmania, Trypanosoma, and Toxoplasma. Their anti-histone deacetylase (HDAC) potency was determined. Moderate to no antileishmanial or antitrypanosomal activity wa...

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Detalles Bibliográficos
Autores principales: Loeuillet, C., Touquet, B., Oury, B., Eddaikra, N., Pons, J.L., Guichou, J.F., Labesse, G., Sereno, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114082/
https://www.ncbi.nlm.nih.gov/pubmed/29414107
http://dx.doi.org/10.1016/j.ijpddr.2018.01.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114082/
https://www.ncbi.nlm.nih.gov/pubmed/29414107
http://dx.doi.org/10.1016/j.ijpddr.2018.01.002

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