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HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

BACKGROUND: Osteosarcoma is the most common primary bone tumor in children and adolescents. Unfortunately, osteosarcoma treatments often fail due to the development of chemoresistance, of which the underlying molecular mechanisms still remain unclear. In this study, we demonstrated that HSP90AA1 gen...

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Detalles Bibliográficos
Autores principales: Xiao, Xin, Wang, Wei, Li, Yuqian, Yang, Di, Li, Xiaokang, Shen, Chao, Liu, Yan, Ke, Xianzhu, Guo, Shuo, Guo, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114771/
https://www.ncbi.nlm.nih.gov/pubmed/30153855
http://dx.doi.org/10.1186/s13046-018-0880-6