A cell autonomous torsinA requirement for cholinergic neuron survival and motor control

Cholinergic dysfunction is strongly implicated in dystonia pathophysiology. Previously (Pappas et al., 2015;4:e08352), we reported that Dlx5/6-Cre mediated forebrain deletion of the DYT1 dystonia protein torsinA (Dlx-CKO) causes abnormal twisting and selective degeneration of dorsal striatal choline...

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Detalles Bibliográficos
Autores principales: Pappas, Samuel S, Li, Jay, LeWitt, Tessa M, Kim, Jeong-Ki, Monani, Umrao R, Dauer, William T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115190/
https://www.ncbi.nlm.nih.gov/pubmed/30117805
http://dx.doi.org/10.7554/eLife.36691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115190/
https://www.ncbi.nlm.nih.gov/pubmed/30117805
http://dx.doi.org/10.7554/eLife.36691

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