A feed forward loop enforces YAP/TAZ signaling during tumorigenesis

In most solid tumors, the Hippo pathway is inactivated through poorly understood mechanisms that result in the activation of the transcriptional regulators, YAP and TAZ. Here, we identify NUAK2 as a YAP/TAZ activator that directly inhibits LATS-mediated phosphorylation of YAP/TAZ and show that NUAK2...

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Detalles Bibliográficos
Autores principales: Gill, Mandeep K., Christova, Tania, Zhang, Ying Y., Gregorieff, Alex, Zhang, Liang, Narimatsu, Masahiro, Song, Siyuan, Xiong, Shawn, Couzens, Amber L., Tong, Jiefei, Krieger, Jonathan R., Moran, Michael F., Zlotta, Alexandre R., van der Kwast, Theodorus H., Gingras, Anne-Claude, Sicheri, Frank, Wrana, Jeffrey L., Attisano, Liliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115388/
https://www.ncbi.nlm.nih.gov/pubmed/30158528
http://dx.doi.org/10.1038/s41467-018-05939-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115388/
https://www.ncbi.nlm.nih.gov/pubmed/30158528
http://dx.doi.org/10.1038/s41467-018-05939-2

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