Cas9 immunity creates challenges for CRISPR gene editing therapies

Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 is a genome-editing technology(1,2) that utilizes archaeal and bacterial Cas9 nucleases to introduce double-stranded breaks in DNA at targeted sites. These breaks can be used to remove, replace, or add pieces of DNA. While not t...

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Detalles Bibliográficos
Autores principales: Crudele, Julie M., Chamberlain, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115392/
https://www.ncbi.nlm.nih.gov/pubmed/30158648
http://dx.doi.org/10.1038/s41467-018-05843-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115392/
https://www.ncbi.nlm.nih.gov/pubmed/30158648
http://dx.doi.org/10.1038/s41467-018-05843-9

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