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Cas9 immunity creates challenges for CRISPR gene editing therapies
Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 is a genome-editing technology(1,2) that utilizes archaeal and bacterial Cas9 nucleases to introduce double-stranded breaks in DNA at targeted sites. These breaks can be used to remove, replace, or add pieces of DNA. While not t...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115392/ https://www.ncbi.nlm.nih.gov/pubmed/30158648 http://dx.doi.org/10.1038/s41467-018-05843-9 |