MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

The c-MYC (MYC) oncoprotein is deregulated in over 50% of cancers, yet regulatory mechanisms controlling MYC remain unclear. To this end, we interrogated the MYC interactome using BioID mass spectrometry (MS) and identified PP1 (protein phosphatase 1) and its regulatory subunit PNUTS (protein phosph...

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Detalles Bibliográficos
Autores principales: Dingar, Dharmendra, Tu, William B., Resetca, Diana, Lourenco, Corey, Tamachi, Aaliya, De Melo, Jason, Houlahan, Kathleen E., Kalkat, Manpreet, Chan, Pak-Kei, Boutros, Paul C., Raught, Brian, Penn, Linda Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115416/
https://www.ncbi.nlm.nih.gov/pubmed/30158517
http://dx.doi.org/10.1038/s41467-018-05660-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115416/
https://www.ncbi.nlm.nih.gov/pubmed/30158517
http://dx.doi.org/10.1038/s41467-018-05660-0

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