Alpha-6 integrin promotes radioresistance of glioblastoma by modulating DNA damage response and the transcription factor Zeb1

Radiotherapy is the cornerstone of glioblastoma (GBM) standard treatment. However, radioresistance of cancer cells leads to an inevitable recurrence. In the present study, we showed that blocking α6-integrin in cells derived from GBM biopsy specimens cultured as neurospheres, sensitized cells to rad...

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Detalles Bibliográficos
Autores principales: Kowalski-Chauvel, Aline, Modesto, Anouchka, Gouaze-andersson, Valerie, Baricault, Laurent, Gilhodes, Julia, Delmas, Caroline, Lemarie, Anthony, Toulas, Christine, Cohen-Jonathan-Moyal, Elizabeth, Seva, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115442/
https://www.ncbi.nlm.nih.gov/pubmed/30158599
http://dx.doi.org/10.1038/s41419-018-0853-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115442/
https://www.ncbi.nlm.nih.gov/pubmed/30158599
http://dx.doi.org/10.1038/s41419-018-0853-x

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