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PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice
Stimulation of white adipose tissue (WAT) browning is considered as a potential approach to treat obesity and metabolic diseases. Our previous studies have shown that phytochemical butein can stimulate WAT browning through induction of Prdm4 in adipocytes. Here, we investigated the effects of butein...
Autores principales: | Song, No-Joon, Chang, Seo-Hyuk, Kim, Suji, Panic, Vanja, Jang, Byung-Hyun, Yun, Ui Jeong, Choi, Jin Hee, Li, Zhen, Park, Ki-Moon, Yoon, Jung-Hoon, Kim, Sunghwan, Yoo, Jae Hyuk, Ling, Jing, Thomas, Kirk, Villanueva, Claudio J., Li, Dean Y., Ahn, Jee-Yin, Ku, Jin-Mo, Park, Kye Won |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115456/ https://www.ncbi.nlm.nih.gov/pubmed/30158592 http://dx.doi.org/10.1038/s41419-018-0904-3 |
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