Cargando…

Full-Profile Pharmacokinetic Study of High Dose Baclofen in Subjects With Alcohol Use Disorder

Baclofen a gamma amino-butyric acid type B (GABA-B) receptor agonist, which has raised some interest for the treatment of alcohol use disorder (AUD), occasionally at dose up to 300 mg/d. We conducted the first full-profile pharmacokinetic study on baclofen in AUD subjects, up to the oral daily dose...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simon, Nicolas, Moirand, Romain, Dematteis, Maurice, Bordet, Régis, Deplanque, Dominique, Rolland, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Psychiatry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115517/ https://www.ncbi.nlm.nih.gov/pubmed/30190685 http://dx.doi.org/10.3389/fpsyt.2018.00385

Ejemplares similares

Pharmacokinetic Studies of Baclofen Are Not Sufficient to Establish an Optimized Dosage for Management of Alcohol Disorder
por: Simon, Nicolas, et al.
Publicado: (2018)

Safety Challenges of Using High Dose Baclofen for Alcohol Use Disorder: A Focused Review
por: Rolland, Benjamin, et al.
Publicado: (2018)

How to Manage Self-Poisoning With Baclofen in Alcohol Use Disorder? Current Updates
por: Franchitto, Nicolas, et al.
Publicado: (2018)

R(+)-Baclofen, but Not S(−)-Baclofen, Alters Alcohol Self-Administration in Alcohol-Preferring Rats
por: Lorrai, Irene, et al.
Publicado: (2016)

Baclofen in alcohol use disorder: An analysis of the data provided by the French “Temporary Recommendation for Use” 2014–2017 cohort
por: de Beaurepaire, Renaud, et al.
Publicado: (2022)

Editorial: Baclofen in the Treatment of Alcohol Use Disorder
por: de Beaurepaire, Renaud, et al.
Publicado: (2019)

The Use of Very High-Doses of Baclofen for the Treatment of Alcohol-Dependence: A Case Series
por: de Beaurepaire, Renaud
Publicado: (2014)

The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective
por: de Beaurepaire, Renaud, et al.
Publicado: (2019)

Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures
por: Durant, Claire F., et al.
Publicado: (2018)

Baclofen and the Alcohol Withdrawal Syndrome-A Short Review
por: Cooney, Gary, et al.
Publicado: (2019)

Use of Baclofen for Alcohol Use Disorders in the United States
por: Garbutt, James C.
Publicado: (2018)

A Review of the Potential Mechanisms of Action of Baclofen in Alcohol Use Disorder
por: de Beaurepaire, Renaud
Publicado: (2018)

Suppressing Effect of Baclofen on Multiple Alcohol-Related Behaviors in Laboratory Animals
por: Colombo, Giancarlo, et al.
Publicado: (2018)

Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders
por: Agabio, Roberta, et al.
Publicado: (2018)

Tailored-Dose Baclofen in the Management of Alcoholism: A Retrospective Study of 144 Outpatients Followed for 3 Years in a French General Practice
por: Pinot, Juliette, et al.
Publicado: (2018)

Pharmacokinetic data on high dose baclofen administration in unhealthy alcohol user in the ICU
por: Vourc'h, Mickael, et al.
Publicado: (2019)

Suppression of Alcohol Dependence Using Baclofen: A 2-Year Observational Study of 100 Patients
por: de Beaurepaire, Renaud
Publicado: (2012)

Previous Leisure-Time Physical Activity Dose Dependently Decreases Ischemic Stroke Severity
por: Deplanque, Dominique, et al.
Publicado: (2012)

Baclofen for the Treatment of Alcohol Use Disorder in Patients With Liver Cirrhosis: 10 Years After the First Evidence
por: Mosoni, Carolina, et al.
Publicado: (2018)

Neurometabolite Levels in Alcohol Use Disorder Patients During Baclofen Treatment and Prediction of Relapse to Heavy Drinking
por: Morley, Kirsten C., et al.
Publicado: (2018)

Preventive Effects of Baclofen but Not Diazepam on Hippocampal Memory and Glucocorticoid Alterations After Prolonged Alcohol Withdrawal in Mice
por: Nadia, Henkous, et al.
Publicado: (2022)

Oral Baclofen Withdrawal Resulting in Hyperactive Delirium: A Case Report
por: Sanders, Benjamin J, et al.
Publicado: (2021)

Baclofen Response in Alcohol Dependent Patients Concurrently Receiving Antidepressants: Secondary Analysis From the BacALD Study
por: Heng, Sovandara, et al.
Publicado: (2018)

Baclofen but Not Diazepam Alleviates Alcohol-Seeking Behavior and Hypothalamic–Pituitary–Adrenal Axis Dysfunction in Stressed Withdrawn Mice
por: Rabat, Yolaine, et al.
Publicado: (2019)

Acamprosate and Baclofen were Not Effective in the Treatment of Pathological Gambling: Preliminary Blind Rater Comparison Study
por: Dannon, Pinhas N., et al.
Publicado: (2011)

Increased Ethanol Consumption Following Chronic Psychosocial Stress: Do Oxytocin and Baclofen Hold any Therapeutic Promise?
por: Lee, Mary R., et al.
Publicado: (2013)

Cognitive Impairments in Alcohol-Dependent Subjects
por: Bernardin, Florent, et al.
Publicado: (2014)

Correlates of Baclofen Effectiveness in Alcohol Dependence
por: Shukla, Lekhansh, et al.
Publicado: (2015)

Baclofen versus lorazepam for alcohol withdrawal
por: Garag, Sagar S., et al.
Publicado: (2019)

Off-Label Baclofen Prescribing Practices among French Alcohol Specialists: Results of a National Online Survey
por: Rolland, Benjamin, et al.
Publicado: (2014)

Low-Dose Baclofen-Induced Encephalopathy in a Healthy Young Adult: Is Baclofen Toxicity Dose-Dependent?
por: Ibeson, Emeka, et al.
Publicado: (2021)

Metabolic and Pharmacokinetic Differentiation of STX209 and Racemic Baclofen in Humans
por: Sanchez-Ponce, Raymundo, et al.
Publicado: (2012)

Obtaining the Optimal Dose in Alcohol Dependence Studies
por: Wages, Nolan A., et al.
Publicado: (2012)

Baclofen approval in france: A balance between two conceptions of medicine
por: Rolland, B.
Publicado: (2021)

Prevalence and Characteristics of Chronic Pain in Buprenorphine and Methadone-Maintained Patients
por: Delorme, Jessica, et al.
Publicado: (2021)

Neuropsychological Impairment in Detoxified Alcohol-Dependent Subjects with Preserved Psychosocial Functioning
por: Martelli, Catherine, et al.
Publicado: (2017)

Incorporating ondansetron and baclofen in alcohol use disorder treatment
por: Ross, Hayley, et al.
Publicado: (2023)

Predictors of Short-Term Alcohol Drinking in Patients with Alcohol Use Disorders during the Third Wave of the COVID-19 Pandemic: Prospective Study in Three Addiction Outpatient Centers in France
por: Constant, Aymery, et al.
Publicado: (2022)

Pharmacokinetic Alteration of Baclofen by Multiple Oral Administration of Herbal Medicines in Rats
por: Kim, Tae Hwan, et al.
Publicado: (2014)

Long-term cognitive impairments following COVID-19: a possible impact of hypoxia
por: Dondaine, Thibaut, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3hp4tjctem0gpqnkf924h68bac