Engineering a bifunctional copper site in the cupredoxin fold by loop-directed mutagenesis

Copper sites in proteins are designed to perform either electron transfer or redox catalysis. Type 1 and Cu(A) sites are electron transfer hubs bound to a rigid protein fold that prevents binding of exogenous ligands and side reactions. Here we report the engineering of two Type 1 sites by loop-dire...

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Detalles Bibliográficos
Autores principales: Espinoza-Cara, Andrés, Zitare, Ulises, Alvarez-Paggi, Damián, Klinke, Sebastián, Otero, Lisandro H., Murgida, Daniel H., Vila, Alejandro J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115626/
https://www.ncbi.nlm.nih.gov/pubmed/30310603
http://dx.doi.org/10.1039/c8sc01444b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115626/
https://www.ncbi.nlm.nih.gov/pubmed/30310603
http://dx.doi.org/10.1039/c8sc01444b

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