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Engineering a bifunctional copper site in the cupredoxin fold by loop-directed mutagenesis
Copper sites in proteins are designed to perform either electron transfer or redox catalysis. Type 1 and Cu(A) sites are electron transfer hubs bound to a rigid protein fold that prevents binding of exogenous ligands and side reactions. Here we report the engineering of two Type 1 sites by loop-dire...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115626/ https://www.ncbi.nlm.nih.gov/pubmed/30310603 http://dx.doi.org/10.1039/c8sc01444b |