Exploring a new ligand binding site of G protein-coupled receptors

Identifying a target ligand binding site is an important step for structure-based rational drug design as shown here for G protein-coupled receptors (GPCRs), which are among the most popular drug targets. We applied long-time scale molecular dynamics simulations, coupled with mutagenesis studies, to...

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Detalles Bibliográficos
Autores principales: Chan, H. C. Stephen, Wang, Jingjing, Palczewski, Krzysztof, Filipek, Slawomir, Vogel, Horst, Liu, Zhi-Jie, Yuan, Shuguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115637/
https://www.ncbi.nlm.nih.gov/pubmed/30310578
http://dx.doi.org/10.1039/c8sc01680a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115637/
https://www.ncbi.nlm.nih.gov/pubmed/30310578
http://dx.doi.org/10.1039/c8sc01680a

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