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Exploring a new ligand binding site of G protein-coupled receptors

Identifying a target ligand binding site is an important step for structure-based rational drug design as shown here for G protein-coupled receptors (GPCRs), which are among the most popular drug targets. We applied long-time scale molecular dynamics simulations, coupled with mutagenesis studies, to...

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Detalles Bibliográficos
Autores principales:	Chan, H. C. Stephen, Wang, Jingjing, Palczewski, Krzysztof, Filipek, Slawomir, Vogel, Horst, Liu, Zhi-Jie, Yuan, Shuguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115637/ https://www.ncbi.nlm.nih.gov/pubmed/30310578 http://dx.doi.org/10.1039/c8sc01680a

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