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A highly site-selective radical sp(3) C–H amination of azaheterocycles

This report describes the development of a novel C–H amination strategy using both a Cu(ii) Lewis acid and an organic hydrogen atom transfer catalyst to activate benzylic C–H bonds adjacent to aromatic N-heterocycles. This simple methodology demonstrates very high selectivity towards azaheterocycles...

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Detalles Bibliográficos
Autores principales: Bentley, Keith W., Dummit, Krysta A., Van Humbeck, Jeffrey F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115697/
https://www.ncbi.nlm.nih.gov/pubmed/30310574
http://dx.doi.org/10.1039/c8sc00590g