Simulation-guided engineering of an enzyme-powered three dimensional DNA nanomachine for discriminating single nucleotide variants

Single nucleotide variants (SNVs) are important both clinically and biologically because of their profound biological consequences. Herein, we engineered a nicking endonuclease-powered three dimensional (3D) DNA nanomachine for discriminating SNVs with high sensitivity and specificity. Particularly,...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yongya, Wang, Guan A., Mason, Sean D., Yang, Xiaolong, Yu, Zechen, Tang, Yanan, Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115701/
https://www.ncbi.nlm.nih.gov/pubmed/30310573
http://dx.doi.org/10.1039/c8sc02761g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115701/
https://www.ncbi.nlm.nih.gov/pubmed/30310573
http://dx.doi.org/10.1039/c8sc02761g

Ejemplares similares