Disruption by SaCas9 Endonuclease of HERV-Kenv, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis

The human endogenous retrovirus (HERV)-K, human mouse mammary tumor virus like-2 (HML-2) subgroup of HERVs is activated in several tumors and has been related to prostate cancer progression and motor neuron diseases. The cellular splicing factor 2/alternative splicing factor (SF2/ASF) is a positive...

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Detalles Bibliográficos
Autores principales: Ibba, Gabriele, Piu, Claudia, Uleri, Elena, Serra, Caterina, Dolei, Antonina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115762/
https://www.ncbi.nlm.nih.gov/pubmed/30087231
http://dx.doi.org/10.3390/v10080412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115762/
https://www.ncbi.nlm.nih.gov/pubmed/30087231
http://dx.doi.org/10.3390/v10080412

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