Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein

Trichosanthin (TCS) is an RNA N-glycosidase that depurinates adenine-4324 in the conserved α-sarcin/ricin loop (α-SRL) of rat 28 S ribosomal RNA (rRNA). TCS has only one chain, and is classified as type 1 ribosome-inactivating protein (RIP). Our structural studies revealed that TCS consists of two d...

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Detalles Bibliográficos
Autores principales: Shi, Wei-Wei, Wong, Kam-Bo, Shaw, Pang-Chui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115768/
https://www.ncbi.nlm.nih.gov/pubmed/30127254
http://dx.doi.org/10.3390/toxins10080335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115768/
https://www.ncbi.nlm.nih.gov/pubmed/30127254
http://dx.doi.org/10.3390/toxins10080335

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