The Impact of p53 Dysfunction in ATR Inhibitor Cytotoxicity and Chemo- and Radiosensitisation

Ataxia telangiectasia mutated and Rad3 related kinase (ATR) signals replication stress and DNA damage to S and G2 arrest and promotes DNA repair. Mutations in p53, critical for G1 checkpoint control, are common in cancer and predicted to confer vulnerability to ATR inhibitors. Reported data on the i...

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Detalles Bibliográficos
Autores principales: Middleton, Fiona K., Pollard, John R., Curtin, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116113/
https://www.ncbi.nlm.nih.gov/pubmed/30127241
http://dx.doi.org/10.3390/cancers10080275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116113/
https://www.ncbi.nlm.nih.gov/pubmed/30127241
http://dx.doi.org/10.3390/cancers10080275

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