Overexpression of GRB2 Enhances Epithelial to Mesenchymal Transition of A549 Cells by Upregulating SNAIL Expression

GRB2 is an adaptor protein which interacts with phosphorylated TGF-β receptor and is critical for mammary tumour growth. We found that TGF-β1-induced EMT increased GRB2 expression in A549 cells (non-small cell lung cancer). Overexpression of GRB2 (A549(GRB2)) enhanced cell invasion while knocking do...

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Detalles Bibliográficos
Autores principales: Mitra, Payal, Kalailingam, Pazhanichamy, Tan, Hui Bing, Thanabalu, Thirumaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116178/
https://www.ncbi.nlm.nih.gov/pubmed/30087284
http://dx.doi.org/10.3390/cells7080097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116178/
https://www.ncbi.nlm.nih.gov/pubmed/30087284
http://dx.doi.org/10.3390/cells7080097

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