Recombinant human proteoglycan-4 reduces phagocytosis of urate crystals and downstream nuclear factor kappa B and inflammasome activation and production of cytokines and chemokines in human and murine macrophages

BACKGROUND: Gout is an inflammatory arthritis caused by monosodium urate monohydrate (MSU) crystals’ joint deposition. MSU phagocytosis by resident macrophages is a key step in gout pathogenesis. MSU phagocytosis triggers nuclear factor kappa B (NFκB) activation and production of cytokines and chemo...

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Detalles Bibliográficos
Autores principales: Qadri, Marwa, Jay, Gregory D., Zhang, Ling X., Wong, Wendy, Reginato, Anthony M., Sun, Changqi, Schmidt, Tannin A., Elsaid, Khaled A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116363/
https://www.ncbi.nlm.nih.gov/pubmed/30157934
http://dx.doi.org/10.1186/s13075-018-1693-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116363/
https://www.ncbi.nlm.nih.gov/pubmed/30157934
http://dx.doi.org/10.1186/s13075-018-1693-x

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