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RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1

BACKGROUND: Endothelial barrier dysfunction characterized by hyperpermeability of the vascular endothelium is a key factor in the pathogenesis of chronic inflammatory diseases and affects clinical outcomes. In states of chronic inflammation, mediators secreted by activated immune cells or vascular e...

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Detalles Bibliográficos
Autores principales: Skaria, Tom, Bachli, Esther, Schoedon, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116367/
https://www.ncbi.nlm.nih.gov/pubmed/30157748
http://dx.doi.org/10.1186/s10020-018-0048-z