Discovery of (phenylureido)piperidinyl benzamides as prospective inhibitors of bacterial autolysin E from Staphylococcus aureus

Autolysin E (AtlE) is a cell wall degrading enzyme that catalyzes the hydrolysis of the β-1,4-glycosidic bond between the N-acetylglucosamine and N-acetylmuramic acid units of the bacterial peptidoglycan. Using our recently determined crystal structure of AtlE from Staphylococcus aureus and a combin...

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Detalles Bibliográficos
Autores principales: Borišek, Jure, Pintar, Sara, Ogrizek, Mitja, Grdadolnik, Simona Golič, Hodnik, Vesna, Turk, Dušan, Perdih, Andrej, Novič, Marjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116672/
https://www.ncbi.nlm.nih.gov/pubmed/30141354
http://dx.doi.org/10.1080/14756366.2018.1493474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116672/
https://www.ncbi.nlm.nih.gov/pubmed/30141354
http://dx.doi.org/10.1080/14756366.2018.1493474

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