Ethenesulfonyl fluoride derivatives as telomerase inhibitors: structure-based design, SAR, and anticancer evaluation in vitro

Based on our previous docking model, in order to carry out more rational drug design, totally 82 vinyl sulfonyl fluorides, including some 2-(hetero)arylethenesulfonyl fluorides and 1,3-dienylsulfonyl fluorides derivatives as potential human telomerase inhibitors were designed and synthesised. The in...

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Detalles Bibliográficos
Autores principales: Chen, Xing, Zha, Gao-Feng, Wang, Jie Quan, Liu, Xin-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116703/
https://www.ncbi.nlm.nih.gov/pubmed/30139286
http://dx.doi.org/10.1080/14756366.2018.1484735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116703/
https://www.ncbi.nlm.nih.gov/pubmed/30139286
http://dx.doi.org/10.1080/14756366.2018.1484735

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