HL156A, a novel pharmacological agent with potent adenosine-monophosphate-activated protein kinase (AMPK) activator activity ameliorates renal fibrosis in a rat unilateral ureteral obstruction model

BACKGROUND: Renal fibrosis is characterized by excessive production and deposition of extracellular matrix (ECM), which leads to progressive renal failure. Adenosine-monophosphate-activated protein kinase (AMPK) is a highly conserved kinase that plays a key role in Smad-3 signaling. Here, we examine...

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Detalles Bibliográficos
Autores principales: Tsogbadrakh, Bodokhsuren, Ju, Kyung Don, Lee, Jinho, Han, Miyeun, Koh, Junga, Yu, Yeonsil, Lee, Hajeong, Yu, Kyung-Sang, Oh, Yun Kyu, Kim, Hyo Jin, Ahn, Curie, Oh, Kook-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116936/
https://www.ncbi.nlm.nih.gov/pubmed/30161162
http://dx.doi.org/10.1371/journal.pone.0201692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116936/
https://www.ncbi.nlm.nih.gov/pubmed/30161162
http://dx.doi.org/10.1371/journal.pone.0201692

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