Cargando…

HL156A, a novel pharmacological agent with potent adenosine-monophosphate-activated protein kinase (AMPK) activator activity ameliorates renal fibrosis in a rat unilateral ureteral obstruction model

BACKGROUND: Renal fibrosis is characterized by excessive production and deposition of extracellular matrix (ECM), which leads to progressive renal failure. Adenosine-monophosphate-activated protein kinase (AMPK) is a highly conserved kinase that plays a key role in Smad-3 signaling. Here, we examine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsogbadrakh, Bodokhsuren, Ju, Kyung Don, Lee, Jinho, Han, Miyeun, Koh, Junga, Yu, Yeonsil, Lee, Hajeong, Yu, Kyung-Sang, Oh, Yun Kyu, Kim, Hyo Jin, Ahn, Curie, Oh, Kook-Hwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116936/ https://www.ncbi.nlm.nih.gov/pubmed/30161162 http://dx.doi.org/10.1371/journal.pone.0201692

Ejemplares similares

Adenosine monophosphate–activated protein kinase in diabetic nephropathy
por: Kim, Yaeni, et al.
Publicado: (2016)

The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation
por: Rundfeldt, Chris, et al.
Publicado: (2012)

Roles of adenosine monophosphate-activated protein kinase (AMPK) in the kidney
por: Zhu, Na, et al.
Publicado: (2022)

Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase α1
por: Kang, Hyo Jae, et al.
Publicado: (2021)

Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells
por: Yamaguchi, Hiroshi, et al.
Publicado: (2014)

Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury
por: Hwang, Jung Hwan, et al.
Publicado: (2015)

Role of the Peroxisome Proliferator-Activated Receptors, Adenosine Monophosphate-Activated Kinase, and Adiponectin in the Ovary
por: Dupont, Joëlle, et al.
Publicado: (2008)

Diabetic conditions modulate the adenosine monophosphate-activated protein kinase of podocytes
por: Ha, Tae-Sun, et al.
Publicado: (2014)

Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy
por: Hajra, A, et al.
Publicado: (2017)

Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus
por: Shi, Yan-Wei, et al.
Publicado: (2019)

Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy
por: Dutta, D, et al.
Publicado: (2017)

Metabolomic profiling of overnight peritoneal dialysis effluents predicts the peritoneal equilibration test type
por: Kim, Hyo Jin, et al.
Publicado: (2023)

Metformin activates type I interferon signaling against HCV via activation of adenosine monophosphate-activated protein kinase
por: Tsai, Wei-Lun, et al.
Publicado: (2017)

Xylazine Activates Adenosine Monophosphate-Activated Protein Kinase Pathway in the Central Nervous System of Rats
por: Shi, Xing-Xing, et al.
Publicado: (2016)

Electroacupuncture preconditioning attenuates ischemic brain injury by activation of the adenosine monophosphate-activated protein kinase signaling pathway
por: Ran, Qiang-qiang, et al.
Publicado: (2015)

Adenosine monophosphate kinase activator α‐lipoic acid: A promising therapeutic agent for metabolic syndrome?
por: Lee, In‐Kyu
Publicado: (2011)

Cereblon Deletion Ameliorates Lipopolysaccharide-induced Proinflammatory Cytokines through 5′-Adenosine Monophosphate-Activated Protein Kinase/Heme Oxygenase-1 Activation in ARPE-19 Cells
por: Kim, Yun Kyu, et al.
Publicado: (2020)

Prenatal hyperbaric normoxia treatment improves healthspan and regulates chitin metabolic genes in Drosophila melanogaster
por: Yu, Suyeun, et al.
Publicado: (2016)

Black Wheat Extracts (Arriheuk) Regulate Adipogenesis and Lipolysis via Adenosine Monophosphate (AMP) Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Signaling Pathways
por: Yoon, Young, et al.
Publicado: (2023)

Activation of Adenosine Monophosphate—Activated Protein Kinase Reduces the Onset of Diet‐Induced Hepatocellular Carcinoma in Mice
por: Schmoll, Dieter, et al.
Publicado: (2020)

Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds
por: Marín-Aguilar, Fabiola, et al.
Publicado: (2017)

LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase
por: Filippov, Sergey, et al.
Publicado: (2014)

Esophageal Artery Pseudoaneurysm and Takayasu Arteritis in a Patient with Autosomal Dominant Polycystic Kidney Disease
por: Kim, Hyunsuk, et al.
Publicado: (2018)

Cyclic adenosine monophosphate-responsive element-binding protein activation predicts an unfavorable prognosis in patients with hepatocellular carcinoma
por: Yu, Lingxiang, et al.
Publicado: (2014)

Structure of Klebsiella pneumoniae adenosine monophosphate nucleosidase
por: Richardson, Brian C., et al.
Publicado: (2022)

Neuroprotective effect of activated 5′-adenosine monophosphate-activated protein kinase on cone system function during retinal inflammation
por: Kamoshita, Mamoru, et al.
Publicado: (2016)

In Silico Design for Adenosine Monophosphate-Activated Protein Kinase Agonist from Traditional Chinese Medicine for Treatment of Metabolic Syndromes
por: Tang, Hsin-Chieh, et al.
Publicado: (2014)

Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)
por: Lee, Myoung-Sun, et al.
Publicado: (2016)

Effects of ischemic preconditioning on mitochondrial and metabolic neruoprotection: 5’ adenosine monophosphate-activated protein kinase and sirtuins
por: Jackson, Charles W, et al.
Publicado: (2018)

Effects of dietary energy level on appetite and central adenosine monophosphate-activated protein kinase (AMPK) in broilers
por: Hu, Xiyi, et al.
Publicado: (2019)

Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase
por: Seneviratne, Anusha, et al.
Publicado: (2020)

Thermostable adenosine 5′-monophosphate phosphorylase from Thermococcus kodakarensis forms catalytically active inclusion bodies
por: Kamel, Sarah, et al.
Publicado: (2021)

Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function
por: Yan, Yan, et al.
Publicado: (2022)

Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase
por: Ali, Akhtar, et al.
Publicado: (2018)

Bidirectional regulation of adenosine 5′‐monophosphate–activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration
por: Xiao, Yuanyuan, et al.
Publicado: (2018)

Identification of Direct Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Structure-Based Virtual Screening and Molecular Docking Approach
por: Huang, Tonghui, et al.
Publicado: (2017)

CYCLIC ADENOSINE MONOPHOSPHATE IN PHAGOCYTIZING GRANULOCYTES AND ALVEOLAR MACROPHAGES
por: Seyberth, H. W., et al.
Publicado: (1973)

Juniperus communis extract ameliorates lipopolysaccharide‐induced acute kidney injury through the adenosine monophosphate–activated protein kinase pathway
por: Lin, Ta‐Chin, et al.
Publicado: (2022)

Molecular characterization of adenosine monophosphate deaminase 1 and its regulatory mechanism for inosine monophosphate formation in triploid crucian carp
por: Zhou, Yonghua, et al.
Publicado: (2022)

Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate‐activated protein kinase‐related kinases and retinoid X receptor α
por: Satoh, Shinya, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qumla6nag55k9jcca32dmag8g5