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Substantial improvement of toyocamycin production in Streptomyces diastatochromogenes by cumulative drug-resistance mutations
Toyocamycin is a member of the nucleoside antibiotic family and has been recognized as a promising fungicide for the control of plant diseases. However, low productivity of toyocamycin remains an important bottleneck in its industrial production. Therefore, dramatic improvements of strains for overp...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117005/ https://www.ncbi.nlm.nih.gov/pubmed/30161195 http://dx.doi.org/10.1371/journal.pone.0203006 |