Cargando…

Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3

OBJECTIVE: Peptidylarginine deiminase 2 (PAD2) and PAD4 are expressed in the synovium of rheumatoid arthritis (RA) patients and catalyze citrullination of arginine residues in proteins targeted by anti-citrullinated protein antibodies (ACPAs). Little is known about the relative importance of PAD2 an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Damgaard, Dres, Bawadekar, Mandar, Senolt, Ladislav, Stensballe, Allan, Shelef, Miriam A., Nielsen, Claus H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117052/ https://www.ncbi.nlm.nih.gov/pubmed/30161253 http://dx.doi.org/10.1371/journal.pone.0203214

Ejemplares similares

Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen
por: Damgaard, Dres, et al.
Publicado: (2014)

Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation
por: Bawadekar, Mandar, et al.
Publicado: (2016)

Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers
por: Damgaard, Dres, et al.
Publicado: (2016)

Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses
por: Mergaert, Aisha M., et al.
Publicado: (2022)

Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase
por: Damgaard, Dres, et al.
Publicado: (2017)

Features of the citrullinating peptidylarginine deiminase enzymes
por: Vossenaar, ER, et al.
Publicado: (2004)

Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase
por: Damgaard, Dres, et al.
Publicado: (2016)

Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases
por: Holmes, Caitlyn L., et al.
Publicado: (2019)

Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development
por: Zhang, Xiaoqian, et al.
Publicado: (2016)

Release of active peptidylarginine deiminase into the circulation during acute inflammation induced by coronary artery bypass surgery
por: Vejlstrup, Anne, et al.
Publicado: (2019)

Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis
por: Massarenti, Laura, et al.
Publicado: (2022)

Identification of potential autoantigens in anti-CCP-positive and anti-CCP-negative rheumatoid arthritis using citrulline-specific protein arrays
por: Poulsen, Thomas B. G., et al.
Publicado: (2021)

Potential Role of Peptidylarginine Deiminase Enzymes and Protein Citrullination in Cancer Pathogenesis
por: Mohanan, Sunish, et al.
Publicado: (2012)

Potential Role for Peptidylarginine Deiminase 2 (PAD2) in Citrullination of Canine Mammary Epithelial Cell Histones
por: Cherrington, Brian D., et al.
Publicado: (2010)

Functional haplotypes in citrullinating enzyme peptidylarginine deiminase 4 are associated with rheumatoid arthritis
por: Yamamoto, K, et al.
Publicado: (2003)

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation
por: Proost, Paul, et al.
Publicado: (2008)

Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase
por: Goulas, Theodoros, et al.
Publicado: (2015)

Activation of Peptidylarginine Deiminase in the Salivary Glands of Balb/c Mice Drives the Citrullination of Ro and La Ribonucleoproteins
por: Rodríguez-Rodríguez, Mayra, et al.
Publicado: (2017)

Peptidylarginine Deiminase Autoimmunity and the Development of Anti–Citrullinated Protein Antibody in Rheumatoid Arthritis: The Hapten–Carrier Model
por: Auger, Isabelle, et al.
Publicado: (2020)

Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4
por: Martín Monreal, María Teresa, et al.
Publicado: (2021)

Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis
por: Engström, Marianne, et al.
Publicado: (2018)

Novel method to quantify peptidylarginine deiminase activity shows distinct citrullination patterns in rheumatoid and juvenile idiopathic arthritis
por: Yu, Karen, et al.
Publicado: (2023)

Peptidylarginine deiminase 2 plays a key role in osteogenesis by enhancing RUNX2 stability through citrullination
por: Kim, Hyun-Jung, et al.
Publicado: (2023)

Putative Roles for Peptidylarginine Deiminases in COVID-19
por: Arisan, Elif Damla, et al.
Publicado: (2020)

In vivo expression of peptidylarginine deiminase in Drosophila melanogaster
por: Mahneva, Olena, et al.
Publicado: (2020)

Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases
por: Méchin, Marie-Claire, et al.
Publicado: (2020)

Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis
por: Demoruelle, M. Kristen, et al.
Publicado: (2021)

Identification of Novel Native Autoantigens in Rheumatoid Arthritis
por: Poulsen, Thomas B. G., et al.
Publicado: (2020)

Analysis of the peptidylarginine deiminase V gene in rheumatoid arthritis
por: Caponi, L, et al.
Publicado: (2003)

Expression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors
por: Wang, Lin, et al.
Publicado: (2010)

Role of peptidylarginine deiminase type 4 in gastric cancer
por: Xin, Jiang, et al.
Publicado: (2016)

Peptidylarginine Deiminases as Drug Targets in Neonatal Hypoxic–Ischemic Encephalopathy
por: Lange, Sigrun
Publicado: (2016)

The peptidylarginine deiminase gene is a conserved feature of Porphyromonas gingivalis
por: Gabarrini, Giorgio, et al.
Publicado: (2015)

Peptidylarginine deiminase 4 promotes age-related organ fibrosis
por: Martinod, Kimberly, et al.
Publicado: (2017)

Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4
por: Guiducci, Eva, et al.
Publicado: (2018)

Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis
por: Liu, Yudong, et al.
Publicado: (2018)

Microglial expression of peptidylarginine deiminase 2 in the prenatal rat brain
por: Asaga, Hiroaki, et al.
Publicado: (2007)

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice
por: Sodré, Fernanda M.C., et al.
Publicado: (2021)

Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4
por: Guo, Jianping, et al.
Publicado: (2021)

Peptidylarginine Deiminase 2 in Host Immunity: Current Insights and Perspectives
por: Wu, Zhenyu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_40f33ihnm217gpnsbd6hhts88e