The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR

BACKGROUND: The antiparasitic agent niclosamide has been demonstrated to inhibit the arthropod-borne Zika virus. Here, we investigated the antiviral capacity of niclosamide against dengue virus (DENV) serotype 2 infection in vitro and in vivo. PRINCIPLE FINDING: Niclosamide effectively retarded DENV...

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Detalles Bibliográficos
Autores principales: Kao, Jo-Chi, HuangFu, Wei-Chun, Tsai, Tsung-Ting, Ho, Min-Ru, Jhan, Ming-Kai, Shen, Ting-Jing, Tseng, Po-Chun, Wang, Yung-Ting, Lin, Chiou-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117097/
https://www.ncbi.nlm.nih.gov/pubmed/30125275
http://dx.doi.org/10.1371/journal.pntd.0006715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117097/
https://www.ncbi.nlm.nih.gov/pubmed/30125275
http://dx.doi.org/10.1371/journal.pntd.0006715

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