ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation

Profilin-1 (PFN1) is a 140-amino-acid protein with two distinct binding sites―one for actin and one for poly-L-proline (PLP). The best-described function of PFN1 is to catalyze actin elongation and polymerization. Thus far, eight DNA mutations in the PFN1 gene encoding the PFN1 protein are associate...

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Detalles Bibliográficos
Autores principales: Kiaei, Mahmoud, Balasubramaniam, Meenakshisundaram, Govind Kumar, Vivek, Shmookler Reis, Robert J., Moradi, Mahmoud, Varughese, Kottayil I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117255/
https://www.ncbi.nlm.nih.gov/pubmed/30166578
http://dx.doi.org/10.1038/s41598-018-31199-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117255/
https://www.ncbi.nlm.nih.gov/pubmed/30166578
http://dx.doi.org/10.1038/s41598-018-31199-7

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