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ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation
Profilin-1 (PFN1) is a 140-amino-acid protein with two distinct binding sites―one for actin and one for poly-L-proline (PLP). The best-described function of PFN1 is to catalyze actin elongation and polymerization. Thus far, eight DNA mutations in the PFN1 gene encoding the PFN1 protein are associate...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117255/ https://www.ncbi.nlm.nih.gov/pubmed/30166578 http://dx.doi.org/10.1038/s41598-018-31199-7 |