Roles of Nmnat1 in the survival of retinal progenitors through the regulation of pro-apoptotic gene expression via histone acetylation

Leber congenital amaurosis (LCA) is a severe, genetically heterogeneous dystrophy of the retina and mutations in the nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) gene is one of causal factors of LCA. NMNAT1 is a nuclear enzyme essential for nicotinamide adenine dinucleotide (NAD) biosy...

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Detalles Bibliográficos
Autores principales: Kuribayashi, Hiroshi, Baba, Yukihiro, Iwagawa, Toshiro, Arai, Eisuke, Murakami, Akira, Watanabe, Sumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117278/
https://www.ncbi.nlm.nih.gov/pubmed/30166529
http://dx.doi.org/10.1038/s41419-018-0907-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117278/
https://www.ncbi.nlm.nih.gov/pubmed/30166529
http://dx.doi.org/10.1038/s41419-018-0907-0

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