High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling

Aldehyde dehydrogenase 1A1 (ALDH1A1) is one of cancer stem cell (CSC) markers, and high ALDH1 expression has been related to drug resistance and facilitated tumor growth. In this study, we investigated the potential involvement of nuclear factor erythroid 2-like 2 (NFE2L2/NRF2) in CSC-like propertie...

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Detalles Bibliográficos
Autores principales: Kim, Donghyeok, Choi, Bo-hyun, Ryoo, In-geun, Kwak, Mi-Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117306/
https://www.ncbi.nlm.nih.gov/pubmed/30166520
http://dx.doi.org/10.1038/s41419-018-0903-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117306/
https://www.ncbi.nlm.nih.gov/pubmed/30166520
http://dx.doi.org/10.1038/s41419-018-0903-4

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