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Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination

Bacillus Calmette–Guérin (BCG) is the only licensed vaccine for tuberculosis (TB) and induces highly variable protection against pulmonary disease in different countries. We hypothesised that DNA methylation is one of the molecular mechanisms driving variability in BCG-induced immune responses. DNA...

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Detalles Bibliográficos
Autores principales: Hasso-Agopsowicz, Mateusz, Scriba, Thomas J., Hanekom, Willem A., Dockrell, Hazel M., Smith, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117309/
https://www.ncbi.nlm.nih.gov/pubmed/30166570
http://dx.doi.org/10.1038/s41598-018-31537-9