Cargando…

NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer

The key negative regulatory gene of the RAS pathway, NF1, is mutated or deleted in numerous cancer types and is associated with increased cancer risk and drug resistance. Even though women with neurofibromatosis (germline NF1 mutations) have a substantially increased breast cancer risk at a young ag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dischinger, Patrick S., Tovar, Elizabeth A., Essenburg, Curt J., Madaj, Zachary B., Gardner, Eve E., Callaghan, Megan E., Turner, Ashley N., Challa, Anil K., Kempston, Tristan, Eagleson, Bryn, Kesterson, Robert A., Bronson, Roderick T., Bowman, Megan J., Graveel, Carrie R., Steensma, Matthew R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117327/ https://www.ncbi.nlm.nih.gov/pubmed/30182054 http://dx.doi.org/10.1038/s41523-018-0080-8

Ejemplares similares

Kinome Profiling of NF1-Related MPNSTs in Response to Kinase Inhibition and Doxorubicin Reveals Therapeutic Vulnerabilities
por: Grit, Jamie L., et al.
Publicado: (2020)

Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling
por: Grit, Jamie L., et al.
Publicado: (2021)

Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers
por: Linklater, Erik S., et al.
Publicado: (2016)

Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D
por: Johnson, Christian W., et al.
Publicado: (2019)

Estrogenic vascular effects are diminished by chronological aging
por: Nicholson, Christopher J., et al.
Publicado: (2017)

Disrupting KATP channels diminishes the estrogen-mediated protection in female mutant mice during ischemia-reperfusion
por: Gao, Jianjiong, et al.
Publicado: (2014)

Ductal tree ablation by local delivery of ethanol prevents tumor formation in an aggressive mouse model of breast cancer
por: Kenyon, Elizabeth, et al.
Publicado: (2019)

Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans
por: Senchuk, Megan M., et al.
Publicado: (2018)

A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity
por: Reinwald, Susan, et al.
Publicado: (2009)

Germline Met Mutations in Mice Reveal Mutation- and Background-Associated Differences in Tumor Profiles
por: Graveel, Carrie R., et al.
Publicado: (2010)

Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities
por: Lanning, Nathan J., et al.
Publicado: (2017)

A Novel Estrogen Receptor β Agonist Diminishes Ovarian Cancer Stem Cells via Suppressing the Epithelial-to-Mesenchymal Transition
por: Banerjee, Ananya, et al.
Publicado: (2022)

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells
por: Valkenburg, Kenneth C., et al.
Publicado: (2011)

Critical analysis of the potential for microRNA biomarkers in breast cancer management
por: Graveel, Carrie R, et al.
Publicado: (2015)

Metal-deficient aggregates and diminished copper found in cells expressing SOD1 mutations that cause ALS
por: Bourassa, Megan W., et al.
Publicado: (2014)

Inhibition of the Pim1 Oncogene Results in Diminished Visual Function
por: Yin, Jun, et al.
Publicado: (2012)

How to Diminish Intolerance
por: Magee, Bryan
Publicado: (1966)

Biotransformation of the Mycotoxin Zearalenone to its Metabolites Hydrolyzed Zearalenone (HZEN) and Decarboxylated Hydrolyzed Zearalenone (DHZEN) Diminishes its Estrogenicity In Vitro and In Vivo
por: Fruhauf, Sebastian, et al.
Publicado: (2019)

Economic evaluation of emergency obstetric care training: a systematic review
por: Banke-Thomas, Aduragbemi, et al.
Publicado: (2017)

Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22
por: Schnepf, Daniel, et al.
Publicado: (2021)

Immunoresponsiveness in endometriosis: implications of estrogenic toxicants.
por: Rier, S E, et al.
Publicado: (1995)

Malignant and Non-malignant Uterine and Vaginal Lesions in Mice Receiving Estrogens and Estrogens and Androgens Simultaneously
por: Gardner, W. U., et al.
Publicado: (1939)

How to Diminish the Numbers of Doctors
por: Bennett, F. Graham
Publicado: (1893)

Mr. Hawkridge, on Diminished Excitement
por: Hawkridge, W. B.
Publicado: (1808)

Over Supply of Diminished Demand
Publicado: (1896)

The Leukemogenic Action of Estrogens in Hybrid Mice
por: Gardner, W. U., et al.
Publicado: (1944)

p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells
por: Brugarolas, James, et al.
Publicado: (1998)

Absence of Hepatic Inactivation of Estrogen in the Monkey
por: van Wagenen, G., et al.
Publicado: (1953)

Priming Melon Defenses with Acibenzolar-S-methyl Attenuates Infections by Phylogenetically Distinct Viruses and Diminishes Vector Preferences for Infected Hosts
por: Kenney, Jaimie R., et al.
Publicado: (2020)

The Diminishing Mortality from Infectious Diseases
Publicado: (1898)

Diminishing returns as a function of disturbance
por: Sorjonen, Kimmo, et al.
Publicado: (2020)

Aging Diminishes Mucociliary Clearance of the Lung
por: Bailey, Kristina L.
Publicado: (2022)

Diminishing storage returns of reservoir construction
por: Li, Yao, et al.
Publicado: (2023)

Inhibition of pituitary tumors in Rb mutant chimeras through E2f4-loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis
por: Parisi, Tiziana, et al.
Publicado: (2008)

Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer
por: Parisi, Tiziana, et al.
Publicado: (2015)

Genetic Interaction between Tmprss2-ERG Gene Fusion and Nkx3.1-Loss Does Not Enhance Prostate Tumorigenesis in Mouse Models
por: Linn, Douglas E., et al.
Publicado: (2015)

Distinct Malignant Behaviors of Mouse Myogenic Tumors Induced by Different Oncogenetic Lesions
por: Hettmer, Simone, et al.
Publicado: (2015)

New Tool for EDC Research: In Vivo Assay Screens for Estrogenic Effects
por: Arnold, Carrie
Publicado: (2015)

Proteome and transcriptome profiling of equine myofibrillar myopathy identifies diminished peroxiredoxin 6 and altered cysteine metabolic pathways
por: Valberg, Stephanie J., et al.
Publicado: (2018)

Escalation of an Otherwise Curable Cancer: Retroperitoneal Mass Destruction Associated With Testicular Seminoma in a Psychiatric Patient
por: Challa, Krishna Teja, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ejc6p1ovfemkfllpnm9kdm3aa8