Class I and II Histone Deacetylase Inhibitors Differentially Regulate Thermogenic Gene Expression in Brown Adipocytes

Class I histone deacetylase inhibitors (HDACis) enhance whole body energy expenditure and attenuate high fat diet-induced insulin resistance. However, it is not clear whether this is exerted directly through activating brown fat thermogenesis. Here, we find that pan-HDACi TSA exerts paradoxical effe...

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Detalles Bibliográficos
Autores principales: Rajan, Anubama, Shi, Hang, Xue, Bingzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117331/
https://www.ncbi.nlm.nih.gov/pubmed/30166563
http://dx.doi.org/10.1038/s41598-018-31560-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117331/
https://www.ncbi.nlm.nih.gov/pubmed/30166563
http://dx.doi.org/10.1038/s41598-018-31560-w

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