Application of the fragment molecular orbital method to discover novel natural products for prion disease

Conformational conversion of the normal cellular isoform of the prion protein PrP(C) into an infectious isoform PrP(Sc) causes pathogenesis in prion diseases. To date, numerous antiprion compounds have been developed to block this conversion and to detect the molecular mechanisms of prion inhibition...

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Detalles Bibliográficos
Autores principales: Choi, Jiwon, Kim, Hyo-Jin, Jin, Xuemei, Lim, Hocheol, Kim, Songmi, Roh, In-Soon, Kang, Hae-Eun, No, Kyoung Tai, Sohn, Hyun-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117342/
https://www.ncbi.nlm.nih.gov/pubmed/30166585
http://dx.doi.org/10.1038/s41598-018-31080-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117342/
https://www.ncbi.nlm.nih.gov/pubmed/30166585
http://dx.doi.org/10.1038/s41598-018-31080-7

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