Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation

Many natural transcription factors are regulated in a pulsatile fashion, but it remains unknown whether synthetic gene expression systems can benefit from such dynamic regulation. Here we find, using a fast-acting, optogenetic transcription factor in Saccharomyces cerevisiae, that dynamic pulsatile...

Descripción completa

Detalles Bibliográficos
Autores principales: Benzinger, Dirk, Khammash, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117348/
https://www.ncbi.nlm.nih.gov/pubmed/30166548
http://dx.doi.org/10.1038/s41467-018-05882-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117348/
https://www.ncbi.nlm.nih.gov/pubmed/30166548
http://dx.doi.org/10.1038/s41467-018-05882-2

Ejemplares similares