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Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation
Many natural transcription factors are regulated in a pulsatile fashion, but it remains unknown whether synthetic gene expression systems can benefit from such dynamic regulation. Here we find, using a fast-acting, optogenetic transcription factor in Saccharomyces cerevisiae, that dynamic pulsatile...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117348/ https://www.ncbi.nlm.nih.gov/pubmed/30166548 http://dx.doi.org/10.1038/s41467-018-05882-2 |