Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains

Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear receptor (NR) involved in cell growth and survival that contains both a DNA-binding domain (DBD) and a ligand-binding domain (LBD). Functionally relevant inter-domain interactions between the DBD and LBD have been observed in sever...

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Detalles Bibliográficos
Autores principales: Huang, Wei, Peng, Yi, Kiselar, Janna, Zhao, Xuan, Albaqami, Aljawharah, Mendez, Daniel, Chen, Yinghua, Chakravarthy, Srinivas, Gupta, Sayan, Ralston, Corie, Kao, Hung-Ying, Chance, Mark R., Yang, Sichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117352/
https://www.ncbi.nlm.nih.gov/pubmed/30166540
http://dx.doi.org/10.1038/s41467-018-06034-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117352/
https://www.ncbi.nlm.nih.gov/pubmed/30166540
http://dx.doi.org/10.1038/s41467-018-06034-2

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