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2-Methyl-5H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-5-imine, an edaravone analog, exerts neuroprotective effects against acute ischemic injury via inhibiting oxidative stress

Oxidative stress plays an indispensable role in the pathogenesis of cerebral ischemia. Inhibiting oxidative stress has been considered as an effective approach for stroke treatment. Edaravone, a free radical scavenger, has been shown to prevent cerebral ischemic injury. However, the clinical efficac...

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Detalles Bibliográficos
Autores principales: Ni, Huanyu, Song, Yixuan, Wu, Haiyin, Chang, Lei, Luo, Chunxia, Zhu, Dongya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117603/
https://www.ncbi.nlm.nih.gov/pubmed/30008465
http://dx.doi.org/10.7555/JBR.32.20180014