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Characterization of the Jomthonic Acids Biosynthesis Pathway and Isolation of Novel Analogues in Streptomyces caniferus GUA-06-05-006A

Jomthonic acids (JAs) are a group of natural products (NPs) with adipogenic activity. Structurally, JAs are formed by a modified β-methylphenylalanine residue, whose biosynthesis involves a methyltransferase that in Streptomyces hygroscopicus has been identified as MppJ. Up to date, three JA members...

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Detalles Bibliográficos
Autores principales: García-Salcedo, Raúl, Álvarez-Álvarez, Rubén, Olano, Carlos, Cañedo, Librada, Braña, Alfredo F., Méndez, Carmen, de la Calle, Fernando, Salas, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117699/
https://www.ncbi.nlm.nih.gov/pubmed/30065171
http://dx.doi.org/10.3390/md16080259