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Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is characterized by intracellular alpha-synuclein (α-syn) inclusions, progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNpc), and activation of the innate and adaptive immune systems. Disruption of immune signaling between the cent...

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Detalles Bibliográficos
Autores principales:	Williams, Gregory P., Schonhoff, Aubrey M., Jurkuvenaite, Asta, Thome, Aaron D., Standaert, David G., Harms, Ashley S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117927/ https://www.ncbi.nlm.nih.gov/pubmed/30165873 http://dx.doi.org/10.1186/s12974-018-1286-2

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