A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport

BACKGROUND: Receptor-mediated transcytosis is one of the major routes for drug delivery of large molecules into the brain. The aim of this study was to develop a novel model of the human blood–brain barrier (BBB) in a high-throughput microfluidic device. This model can be used to assess passage of l...

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Detalles Bibliográficos
Autores principales: Wevers, Nienke R., Kasi, Dhanesh G., Gray, Taylor, Wilschut, Karlijn J., Smith, Benjamin, van Vught, Remko, Shimizu, Fumitaka, Sano, Yasuteru, Kanda, Takashi, Marsh, Graham, Trietsch, Sebastiaan J., Vulto, Paul, Lanz, Henriëtte L., Obermeier, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117964/
https://www.ncbi.nlm.nih.gov/pubmed/30165870
http://dx.doi.org/10.1186/s12987-018-0108-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117964/
https://www.ncbi.nlm.nih.gov/pubmed/30165870
http://dx.doi.org/10.1186/s12987-018-0108-3

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