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Construction of an overexpression library for Mycobacterium tuberculosis

There is a pressing need to develop novel anti-tubercular drugs. High-throughput phenotypic screening yields chemical series that inhibit bacterial growth. Target identification for such series is challenging, but necessary for optimization of target engagement and the development of series into cli...

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Detalles Bibliográficos
Autores principales: Melief, Eduard, Kokoczka, Rachel, Files, Megan, Bailey, Mai Ann, Alling, Torey, Li, Hongye, Ahn, James, Misquith, Ayesha, Korkegian, Aaron, Roberts, David, Sacchettini, James, Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118195/
https://www.ncbi.nlm.nih.gov/pubmed/30197930
http://dx.doi.org/10.1093/biomethods/bpy009