Cargando…

Trichostatin A promotes GLI1 degradation and P21 expression in multiple myeloma cells

BACKGROUND: Histone deacetylase inhibitors are promising drugs for the future application in cancer therapy. Trichostatin A (TSA), a histone deacetylase inhibitor, exhibits effective antitumor effects in various cancers. However, the effects and underlying mechanisms of TSA on multiple myeloma (MM)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geng, Yan, Liu, Jing, Xie, Ying, Jiang, Hongmei, Zuo, Kai, Li, Tao, Liu, Zhiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118243/ https://www.ncbi.nlm.nih.gov/pubmed/30214285 http://dx.doi.org/10.2147/CMAR.S167330

Ejemplares similares

Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma
por: Lazzari, Elisa, et al.
Publicado: (2017)

Anti-Proliferative Activity of HPOB against Multiple Myeloma Cells via p21 Transcriptional Activation
por: Liu, Linlin, et al.
Publicado: (2018)

Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells
por: Doñas, Cristian, et al.
Publicado: (2013)

Deacetylation induced nuclear condensation of HP1γ promotes multiple myeloma drug resistance
por: Li, Xin, et al.
Publicado: (2023)

Hypoxia-induced CREB cooperates MMSET to modify chromatin and promote DKK1 expression in multiple myeloma
por: Xu, Yinyin, et al.
Publicado: (2021)

PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation
por: Yang, Jun, et al.
Publicado: (2021)

miR‐17‐3p promotes the proliferation of multiple myeloma cells by downregulating P21 expression through LMLN inhibition
por: Xiang, Pu, et al.
Publicado: (2021)

Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation
por: Deng, Zhantao, et al.
Publicado: (2016)

The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways
por: Hrgovic, Igor, et al.
Publicado: (2016)

Dual regulation of P-glycoprotein expression by Trichostatin A in cancer cell lines
por: Balaguer, Trinidad Mata, et al.
Publicado: (2012)

LncRNA-uc002mbe.2 Interacting with hnRNPA2B1 Mediates AKT Deactivation and p21 Up-Regulation Induced by Trichostatin in Liver Cancer Cells
por: Chen, Ting, et al.
Publicado: (2017)

NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts
por: Ye, Ling, et al.
Publicado: (2018)

Trichostatin A Promotes the Conversion of Astrocytes to Oligodendrocyte Progenitors in a Defined Culture Medium
por: Zare, Leila, et al.
Publicado: (2019)

MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21(Cip1)
por: Mei, Anna Huo-Chang, et al.
Publicado: (2020)

Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation
por: Zhang, Rui, et al.
Publicado: (2017)

Chromosome 1q21 abnormalities in multiple myeloma
por: Schmidt, Timothy M., et al.
Publicado: (2021)

Promoter DNA hypermethylation of TaGli-γ-2.1 positively regulates gluten strength in bread wheat
por: Zhou, Zhengfu, et al.
Publicado: (2021)

BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma
por: Kurata, Keiji, et al.
Publicado: (2023)

P830: IDENTIFICATION OF NOVEL TARGET GENES CORRELATED WITH 1Q21 AMPLIFICATION IN PATIENTS WITH SMOLDERING MYELOMA AND MULTIPLE MYELOMA
por: Thomas Iannozzi, Nicolas, et al.
Publicado: (2023)

Cancer-associated fibroblast-derived exosome microRNA-21 promotes angiogenesis in multiple myeloma
por: Miaomiao, Sun, et al.
Publicado: (2023)

FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21
por: Zhang, Long, et al.
Publicado: (2019)

Histone Deacetylase Inhibitor Trichostatin A Reduces Endothelial Cell Proliferation by Suppressing STAT5A-Related Gene Transcription
por: Li, Yize, et al.
Publicado: (2021)

Trichostatin A inhibits the activation of Hepatic stellate cells by Increasing C/EBP-α Acetylation in vivo and in vitro
por: Ding, Di, et al.
Publicado: (2018)

Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes
por: Karagiannis, Tom C, et al.
Publicado: (2010)

Trichostatin A activates FOXO1 and induces autophagy in osteosarcoma
por: Bai, Yunjuan, et al.
Publicado: (2018)

BMI1 regulates multiple myeloma-associated macrophage’s pro-myeloma functions
por: Zhang, Danfeng, et al.
Publicado: (2021)

Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells
por: Sharma, Priyanka, et al.
Publicado: (2010)

Matrix metalloproteinases and tissue inhibitors in multiple myeloma: promote or inhibit?
por: Li, Yan-Ying, et al.
Publicado: (2023)

HDAC inhibitor Trichostatin A suppresses adipogenesis in 3T3-L1 preadipocytes
por: Lv, Xin, et al.
Publicado: (2021)

Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction
por: Hsing, Chung-Hsi, et al.
Publicado: (2015)

Histone deacetylase inhibitor, Trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells
por: Alao, John P, et al.
Publicado: (2006)

DEPTOR is linked to a TORC1-p21 survival proliferation pathway in multiple myeloma cells
por: Yang, Yonghui, et al.
Publicado: (2014)

Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells
por: DU, RUIXIA, et al.
Publicado: (2016)

IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in multiple myeloma with 1q21 amplification
por: Teoh, Phaik Ju, et al.
Publicado: (2020)

Posttranslational modification of Aurora A‐NSD2 loop contributes to drug resistance in t(4;14) multiple myeloma
por: Jiang, Hongmei, et al.
Publicado: (2022)

Trichostatin A Rescues the Disrupted Imprinting Induced by Somatic Cell Nuclear Transfer in Pigs
por: Huan, Yanjun, et al.
Publicado: (2015)

TRIM21 enhances bortezomib sensitivity in multiple myeloma by halting prosurvival autophagy
por: Chen, Jing, et al.
Publicado: (2023)

BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma
por: Weisberg, Ellen, et al.
Publicado: (2022)

The tripeptide N-Cbz-βGly-Gly-Gly-Obz
por: Nicholas, Sumesh
Publicado: (2015)

Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica
por: Ehrenkaufer, Gretchen M, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_or34qtm4p8qa2liucc4o2g7u33